Streptozotocin Diabetes in Monkeys and Dogs, and Its Prevention by Nicotinamide

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Abstract
Summary Streptozotocin produces a permanent diabetic state in monkeys and dogs which can be prevented by the use of oral or intravenous nicotinamide. A total dose that is diabetogenic in the monkey when administered by a single injection is ineffective in producing a diabetic state when administered over a 4–14 day period. This observation may have relevance in regard to the schedule employed in the treatment of malignant insulinoma in man. Rhesus monkeys observed in a persistent diabetic state for up to two years failed to demonstrate any of the known extra pancreatic complications of human diabetes mellitus. There was no evidence of renal tumor induction in these animals, as had previously been reported in rats.

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