Regional Gas Exchange and Cellular Metabolic Activity in Ventilator-induced Lung Injury
- 1 April 2007
- journal article
- abstracts
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 106 (4) , 723-735
- https://doi.org/10.1097/01.anes.0000264748.86145.ac
Abstract
VENTILATOR-INDUCED lung injury (VILI) can contribute to the morbidity and mortality of patients with acute lung injury (ALI).1 Overdistension, repetitive alveolar derecruitment and recruitment, and large tidal excursion are three physical determinants of VILI.2–10 Because the pulmonary inflammatory process triggered by these physical stimuli is an important pathogenic event of VILI, a method to assess activation of inflammatory cells in the lung noninvasively and in vivo could be valuable, especially if it provided topographical information allowing identification of lung regions most affected by the inflammatory process of VILI.Keywords
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