Double-Blind Study of Children with Hyperkinetic Syndrome Treated with Multi-Allergen Extract Sublingually

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Abstract
The purpose of this research was to determine, by double-blind studies, whether the hyperkinetic syndrome is due, in part, to certain foods, food colors, and inhalant allergens and, if so, whether it can be treated by specific immunotherapy sublingually. The children were tested by the provocative intradermal and sublingual method, and an optimal or neutralizing dose was obtained that was included in a multiallergen extract for sublingual treatment. The study was conducted over a six-week period-three weeks of treatment with the allergen extract and three weeks with a placebo. Each child's behavior was monitored weekly by parents, teachers, and a psychologist. Significant improvement was reported in 11 of 14 participants during the three weeks of treatment vs placebo. One child did not complete the study. Possible reasons for failure will be discussed.

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