Influence of Pregnancy upon Hypertension Induced in Rats by Sodium Chloride and Desoxycorticosterone.

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Abstract
Desoxycorticosterone acetate (DCA) and NaCl, in amts. sufficient to cause hypertension do not interfere with conception, implantation or normal delivery in rats. When pregnancy is superimposed upon DCA-sodium hypertension, the blood pressure and fluid balance are not affected. There may be a transient increase of proteinuria during the last third of pregnancy. The failure of the elevated blood pressure to fall during late pregnancy, as it regularly does in exptl. renal hypertension, suggests a difference in the chemical mediation of the 2 types of hypertension.