Pulmonary Effects of Topical Timolol
- 1 June 1980
- journal article
- case report
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 140 (6) , 843-4
- https://doi.org/10.1001/archinte.1980.00330180117034
Abstract
Timolol, a beta-adrenergic blocking agent, recently became available for the treatment of glaucoma. We report the occurrence of acute bronchospasm in a previously asymptomatic asthmatic patient following topical use of timolol. Therapy with the drug was discontinued, and four weeks later the patient was challenged with two drops of 0.5% timolol. A 25% decrease in forced expiratory volume at one second (FEV1) was demonstrated at one hour. The fall in FEV1 was even greater (47%) when the patient was rechallenged with four drops. We emphasize the need to avoid topical beta-adrenergic blocking agents in asthmatic patients.Keywords
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