Sensitization of the smooth muscle by prostaglandin E1 contributes to reversal of drug-induced inhibition of the guinea-pig ileum

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Abstract
Prostaglandin (PG)E1 reverses drug-induced inhibition of the electrically stimulated guineapig ileum. The effect of PGE1 is in part related to a sensitizing action on the smooth muscle and in part to an increased acetylcholine release from the myenteric plexus.