ELECTROFOCUSING PATTERNS OF FUCOSYL-TRANSFERASE ACTIVITY IN PLASMA OF PATIENTS WITH CHRONIC GRANULOCYTIC-LEUKEMIA

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (10) , 3576-3578
Abstract
Fucosyltransferase activity was measured in plasma samples obtained from patients with chronic granulocytic leukemia in different disease stages. Total enzyme activity was generally elevated in untreated and in stable disease; a marked further elevation was noted 30-60 days before development of blast crisis. Electrofocusing studies indicate the presence of 3 major enzymes. The level of enzyme which focused at pH 5.6 was elevated in untreated disease and rose markedly during blastic transformation. A 2nd enzyme focused at pH 5.1 and appeared to be related to marrow erythroid turnover. A 3rd enzyme with pl = 4.7 was elevated only during marrow regeneration which followed myelosuppressive therapy. The enzyme with pl = 5.6 may be a specific marker in chronic granulocytic leukemia.