Two-Dimensional Mapping of Copper and Zinc in Liver Sections by Laser Ablation–Inductively Coupled Plasma Mass Spectrometry
Open Access
- 1 November 2003
- journal article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 49 (11) , 1916-1923
- https://doi.org/10.1373/clinchem.2003.022046
Abstract
Background: Metals are not homogeneously distributed in organ tissues. Although most mapping techniques, such as histologic staining methods, have been developed for element imaging on a subcellular level, many suffer from either low precision or poor detection limits. Therefore, small variations in elemental distribution cannot be identified. We developed a method for two-dimensional mapping of trace elements to identify the influence of metabolic zonation by the liver on trace element distribution.Keywords
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