ANTIMETABOLITES OF PANTOTHENIC-ACID, UREIDO-DERIVATIVES AND CARBAMOYL-DERIVATIVES
- 1 January 1975
- journal article
- research article
- Vol. 33 (3) , 433-443
Abstract
Pantothenic acid analogs were synthesized that contain alkyl and/or arylureido and carbamate functions in the .beta.-alanyl portion of the amide moiety of the vitamin. The analogs are inhibitory to growth of lactic acid bacteria at concentrations as low as 0.6 .mu.g/ml, and the inhibitions are competitively reversed by supplements of pantothenic acid. The carbamate derivatives are more toxic to growth of Lactobacillus plantarum 8014 and Pediococcus cerevisiae 8042 than the ureido analogs, and chloro-substituents on the aryl group significantly increase the toxicity of the analogs.This publication has 5 references indexed in Scilit:
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