β-Particle–Emitting Radioactive Stent Implantation
- 19 October 1999
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Circulation
- Vol. 100 (16) , 1684-1689
- https://doi.org/10.1161/01.cir.100.16.1684
Abstract
Background—This study represents the Heart Center Rotterdam’s contribution to the Isostents for Restenosis Intervention Study, a nonrandomized multicenter trial evaluating the safety and feasibility of the radioactive Isostent in patients with single coronary artery disease. Restenosis after stent implantation is primarily caused by neointimal hyperplasia. In animal studies, β-particle–emitting radioactive stents decrease neointimal hyperplasia by inhibiting smooth muscle cell proliferation. Methods and Results—The radioisotope 32P, a β-particle emitter with a half-life of 14.3 days, was directly embedded into the Isostent. The calculated range of radioactivity was 0.75 to 1.5 μCi. Quantitative coronary angiography measurements were performed before and after the procedure and at 6-month follow-up. A total of 31 radioactive stents were used in 26 patients; 30 (97%) were successfully implanted, and 1 was embolized. Treated lesions were in the left anterior descending coronary artery (n=12), the right coron...Keywords
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