A Convenient One-Step Method of Converting Electron-Rich Aromatic Aldehydes into Nitriles
- 1 January 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1992 (07) , 641-642
- https://doi.org/10.1055/s-1992-26185
Abstract
Electron-rich aromatic aldehydes react with sodium azide in the presence of aluminum chloride in boiling tetrahydrofuran to give the corresponding nitriles in good yields, while electron-deficient or hindered aromatic aldehydes lead to (diazidomethyl)arenes in moderate yield under similar conditions.Keywords
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