Role of Polo-like Kinase CDC5 in Programming Meiosis I Chromosome Segregation
Top Cited Papers
- 18 April 2003
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 300 (5618) , 482-486
- https://doi.org/10.1126/science.1081846
Abstract
Meiosis is a specialized cell division in which two chromosome segregation phases follow a single DNA replication phase. The budding yeast Polo-like kinase Cdc5 was found to be instrumental in establishing the meiosis I chromosome segregation program. Cdc5 was required to phosphorylate and remove meiotic cohesin from chromosomes. Furthermore, in the absence of CDC5 kinetochores were bioriented during meiosis I, and Mam1, a protein essential for coorientation, failed to associate with kinetochores. Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5.Keywords
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