Synthesis of substituted 5-fluoro-5, 6-dihydropyrimidines
- 1 November 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 2 (11) , 2177-2182
- https://doi.org/10.1093/nar/2.11.2177
Abstract
The reaction of 5-substituted uracils with fluorine in acetic acid and other solvents and the following treatment with different alcohols yielded the corresponding 5-fluoro-5,6-substituted-5,6-dihydropyrimidines. Thymine gave 5-fluoro-5-methyl-6-alkoxy-5,6-dihydropyrimidines. 5-Halogeno uracils and 5-nitro uracil were converted into 5-fluoro-5-halogeno-6-hydrozy-5,6-dihydropyrimidines and the 5-nitroanalogue, respectively. The structures of the compounds were confirmed by mass spectrometry.Keywords
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