Morphological, Biochemical, and Genetic Support for an Apolipoprotein E Effect on Microtubular Metabolisma
- 1 January 1996
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 777 (1) , 146-157
- https://doi.org/10.1111/j.1749-6632.1996.tb34413.x
Abstract
There are two distinct viewpoints on the association of the inheritance of apolipoprotein E (APOE) alleles and the age of onset distribution of Alzheimer's disease (AD): genetic and phenotypic expression. There have been multiple corroborations of the APOE‐ε4 association with Alzheimer's disease in populations around the world in clinic based studies as well as emerging epidemiological studies. The genetic data do not imply mechanism of pathogenesis. The phenotypic expression of AD has been based in theories based on amyloid plaques or neurofibrillary tangles. ApoE protein interacts with both β‐amyloid and tau in an isoform‐specific manner. The interaction with tau had been thought to be an in vitro artifact, since apoE had not been previously localized to theKeywords
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