Zoladex and Flutamide Versus Bilateral Orchiectomy
- 1 September 1990
- Vol. 66 (S5) , 1045-1057
- https://doi.org/10.1002/cncr.1990.66.s5.1045
Abstract
A total of 327 patients with metastatic prostatic cancer were randomized to either bilateral orchiectomy or treatment with zoladex depot supplemented by flutamide 250 mg 3 qid. Statistically significant increases in time to subjective and objective progression were recorded in favor of the combination treatment. No differences in time to death by cancer or overall death were recorded. The clinical significance of these differences will be reassessed once additional follow-up is available and further analysis of the overall clinical material has been carried out. Cancer 66:1045–1057, 1990.Keywords
This publication has 5 references indexed in Scilit:
- A Controlled Trial of Leuprolide with and without Flutamide in Prostatic CarcinomaNew England Journal of Medicine, 1989
- Long-Term Therapy with a Depot Luteinizing Hormone-Releasing Hormone Analogue (Zoladex) in Patients with Advanced Prostatic CarcinomaJournal of Urology, 1988
- Analysis of the androgenic activity of synthetic “progestins” currently used for the treatment of prostate cancerThe Journal of Steroid Biochemistry and Molecular Biology, 1987
- DHT in prostate cancer tissue— a guide to management and therapyThe Prostate, 1985
- The Androgenic Action of Adrenal Implants in the Ventral Prostate of Adult, Castrated, and Oestrogen‐treated RatsActa Pharmacologica et Toxicologica, 1971