EFFECT OF DIETARY VITAMIN-E ON DIMETHYLHYDRAZINE-INDUCED COLONIC TUMORS IN MICE

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (4) , 1329-1331
Abstract
The effect of variations in dietary vitamin E on the incidence of dimethylhydrazine-induced colonic tumors in mice was investigated. Two groups of 65 LACA mice were given 28 weekly s.c. injections of dimethylhydrazine. The only difference in the management of the 2 groups was the dietary content of vitamin E; 1 group received 10 mg/kg, and the other group received 600 mg/kg. Of these 2 groups, 42 and 51 mice, respectively, survived, and there were significantly more adenomas, more adenomas with pleomorphic cytology and more invasive carcinoma in the group receiving a low vitamin E supplement to their diet. Vitamin E may play a part in the multifactorial effect of diet on colorectal carcinogenesis.

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