Effect of Norepinephrine on in vitro Histamine Release from Rat Mast Cells

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Abstract
The effect of norepinephrine on compound 48/80-induced histamine release from rat peritoneal mast cells, was studied in an in vitro system. It was found that norepinephrine, within the concentration range 10––5––10––3M, exerts a significant, dose-related, repressive effect. This effect is greatly potentiated by the β-antagonist practolol (10––3 M), throughout the concentration range of 10––5–10––3M norepinephrine. Methoxyamine, a selective α-adrenergic agonist, also represses histamine release in a dose-dependent manner; however, it is not as potent as norepinephrine. The present results would seem to suggest that the repressive effect on histamine release, observed within a low concentration range of norepinephrine, may be due to α-adrenoceptor mechanisms.