The evaluation of bioequivalence using nonparametric procedures
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Communications in Statistics - Theory and Methods
- Vol. 19 (11) , 4153-4165
- https://doi.org/10.1080/03610929008830433
Abstract
Applications of nonparametric methods to the evaluation of bioequiv-alence for two treatments are presented for independent samples and for a crossover design. Included are procedures for testing for equivalence in location, in dispersion, and in general. Also presented are procedures for the calculation of confidence limits. A general strategy for the evaluation of bioequivalence is developed which involves both hypothesis testing and the calculation of confidencelimits for parameters which characterize departures from equivalene.Keywords
This publication has 13 references indexed in Scilit:
- The performance of the two‐stage analysis of two‐treatment, two‐period crossover trialsStatistics in Medicine, 1989
- 328. Note: The Use of None-Parametric Methods in the Statistical Analysis of the Two-Period Change-Over DesignPublished by JSTOR ,1972
- Certain Uncorrelated and Independent Rank StatisticsJournal of the American Statistical Association, 1971
- Approximate Small-Sample Distributions for Multivariate Two-Sample Nonparametric TestsPublished by JSTOR ,1971
- A nonparametric test for bivariate symmetryBiometrika, 1971
- Query 10: Confidence Limits from Rank TestsTechnometrics, 1965
- Robustness of Some Procedures for the Two-Sample Location ProblemJournal of the American Statistical Association, 1964
- Estimates of Location Based on Rank TestsThe Annals of Mathematical Statistics, 1963
- Rank-Sum Tests for DispersionsThe Annals of Mathematical Statistics, 1960
- On a Test of Whether one of Two Random Variables is Stochastically Larger than the OtherThe Annals of Mathematical Statistics, 1947