Surface Charge of Erythrocytes in Paroxysmal Nocturnal Haemoglobinuria

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Abstract
The electrophoretic mobility of erythrocytes from 3 patients with PNH [paroxysmal nocturnal hemoglobinuria] was measured by standard techniques. Erythrocyte mobility is a measure of the net negative surface charge of these cells. In each of the 3 patients studied, the mobility was significantly increased over normal cells indicating that there was an increase in negative surface charge on PNH erythrocytes. Following the Ham''s and sucrose lysis tests, surviving cells showed mean mobilities that were not statistically different from normal cells. This suggests that these cells with higher surface charge were vulnerable to complement lysis.