Rapid Transport of Noradrenaline in Adrenergic Axons of Rat Sciatic Nerve Distal to a Crush1
- 1 July 1975
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 94 (3) , 386-392
- https://doi.org/10.1111/j.1748-1716.1975.tb05898.x
Abstract
The transport of NA in the rat sciatic nerve distal to a crush was studied in 5 mm segments. The disappearance of a NA fraction in consecutive segments with time after crushing (0–12 h) was interpreted to indicate a proximo‐distal migration of a NA fraction into further distal parts of the nerve. This transportable NA fraction was found to be about 45% of the NA in normal sciatic nerves and migrated at a rate of approximately 8 mm/h. The apparently non‐mobile fraction (55%) was probably mainly located in vaso‐constrictor nerve terminals of the blood vessels supplying the nerve. This non‐mobile NA fraction does not contribute to the NA accumulations proximal to a crush. Thus, when calculating the rate of transport of any substance from accumulation experiments, corrections for a non‐mobile fraction must always be considered.Keywords
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