Insulin-Like Growth Factor I and II Gene Expression in Balb/C Mouse Liver during Postnatal Development

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Abstract
We studied the developmental shift from IGF-II to IGF-I mRNA synthesis in Balb/C mouse liver. IGF-I mRNA levels were low at birth, increased with age to peak at weaning, and IGF-I gene expression again increased during puberty. IGF-II expression was high during early postnatal development, but became nondetectable at weaning. Thus in early life there is a reciprocal relationship of rising IGF-I and falling IGF-II mRNA. Northern analysis revealed four IGF-I mRNA transcripts ranging from 1.1–7.0 kb, with the 1.1 kb being the most prominent. Five IGF-II transcripts ranging from 1.7–4.0 kb were found, with the 4,0 kb being the most prominent. The pattern of Serum IGF-I and IGF-II values paralleled liver IGF-I and IGF-II mRNA levels.

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