Obesity from eating elicited by daily stimulation of hypothalamus

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Abstract
Rats who were forced to overeat wet mash by electrical stimulation of the lateral hypothalamus 2 hr/day for 31 days became obese by maintaining an intake and rate of weight gain far greater than nonstimulated animals or animals similarly stimulated without food present. The rats stimulated without food present gained less weight over the 31-day period, ate less in the hour after each stimulation, but were not significantly different from the nonstimulated rats in total daily intake. In a second experiment, using a high-fat diet instead of wet mash, rats stimulated to eat varying fractions (0, 33, 66, 100%) of their normal daily intake in a short time each day were found abruptly to reduce their intake the rest of the day so that total daily intake remained normal.

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