Pyrimidine derivatives and related compounds. Part 42. Isolation of the intermediates in the ring transformation of 1,3-oxazine-2,4-diones into pyrimidines and pyrazoles, and their structure determination by 15N nuclear magnetic resonance analysis
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 473-475
- https://doi.org/10.1039/p19820000473
Abstract
Reaction of the 6-methyl-1,3-oxazine-2,4-diones (1) and (2) with hydrazine hydrate at room temperature gave the 6-hydroxy-5,6-dihydrouracils (7a) and (8a). The structures of the products were determined by 15N n.m.r. analysis. The mechanism of the ring transformation of 1,3-oxazines into pyrimidines and pyrazoles is discussed.Keywords
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