The neuromuscular blocking action of a series of bicyclic bis‐onium esters

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Abstract
1 Thirteen bicyclic dicholine esters have been tested on mammalian and avian skeletal muscle preparations. 2 One of the compounds exhibited depolarizing activity in all the preparations. 3 Three of the compounds exhibited depolarizing or dual-blocking activity in avian and denervated mammalian preparations, but exhibited non-depolarizing blocking activity in innervated mammalian preparations. 4 The remaining compounds exhibited non-depolarizing blocking activity with evidence of an additional facilitatory action. 5 The activity exhibited was dependent upon the onium substituents and the structure of the bicyclic ring. 6 All the compounds exhibited a choline-reversible block in the rapidly stimulated rat diaphragm preparation and six of them exhibited a secondary choline-reversible block of the rapidly stimulated cat tibialis anterior muscle.

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