Stereospecificity of oxidation at C-19 in oestrogen biosynthesis
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 6,p. 185-186
- https://doi.org/10.1039/c39750000185
Abstract
A method has been devised for determining the configuration of samples of 19-acetoxy-Δ5-androgens stereospecifically labelled at C-19; with the help of such samples it is shown that in the biological conversion of 19-hydroxyandrogens into oestrogen the pro-R hydrogen atom from C-19 is removed as a proton and the pro-S hydrogen atom is incor porated into formic acid.Keywords
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