Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.
- 1 January 1996
- journal article
- Published by The Endocrine Society in Endocrinology
- Vol. 137 (1) , 375-378
- https://doi.org/10.1210/endo.137.1.8536638
Abstract
The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to human papillary thyroid carcinomas, particularly in the nuclear cytologic features and the presence of local invasion. Our findings indicate that ret/PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papillary thyroid carcinoma.Keywords
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