Human Interferon and Cell Growth Inhibition. IV. The Effect of Isolated Interferon Components on the Growth of Different Human Cell Lines
- 1 January 1983
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 3 (3) , 327-332
- https://doi.org/10.1089/jir.1983.3.327
Abstract
Antiviral and cell growth inhibitory components isolated from a partially purified human alpha interferon (HuIFN-α) preparation were tested for effect on the growth of 11 different human cell lines. The effect of the components was compared with the effect of purified HuIFN-α. In all sensitive cells, except Daudi and EB4, a strong reduction in anticellular effect was observed with the antiviral component compared with IFN. The results confirm that at least some of the anticellular effect of IFN can be isolated from the antiviral activity and it is suggested that more than one mechanism may be responsible for growth regulation by IFN preparations.Keywords
This publication has 6 references indexed in Scilit:
- Electrophoretically pure mouse interferon exerts multiple biologic effects.Proceedings of the National Academy of Sciences, 1979
- Purification of mouse L cell interferon. Essentially pure preparations with associated cell growth inhibitory activity.Journal of Biological Chemistry, 1978
- Human interferon and cell growth inhibition. III. Separation of activities by treatment with sodium dodecyl sulphateBiochemical and Biophysical Research Communications, 1978
- Effect of interferon on lymphocyte transformation and nuclear antigen production by Epstein–Barr virusNature, 1976
- Separation of antiviral activity of human interferon from cell growth inhibitory effectNature, 1975
- INTERFERON AND CELL DIVISION, I. INHIBITION OF THE MULTIPLICATION OF MOUSE LEUKEMIA L 1210 CELLS In Vitro BY INTERFERON PREPARATIONSProceedings of the National Academy of Sciences, 1970