The Localized Hemolysis-in-Gel Method Adapted to the Detection of Spleen Cells Releasing Virus-Specific Antibodies
Open Access
- 1 May 1970
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 104 (5) , 1184-1186
- https://doi.org/10.4049/jimmunol.104.5.1184
Abstract
The localized hemolysis-in-gel method has been adapted to the detection of single cells releasing antibodies to influenza A virus. In mice infected with influenza A the number of cells releasing IgM antibodies specific for the inner component of the virus (RNP antigen) begins to rise between 24 and 36 hours after virus inoculation, reaches a maximum on the 4th day, and then decreases rapidly to the background level by day 20.Keywords
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