.BETA.-Eudesmol (a main component of Atractylodes lancea)-induced potentiation of depolarizing neuromuscular blockade in diaphragm muscles of normal and diabetic mice.
- 1 January 1989
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 50 (1) , 69-71
- https://doi.org/10.1254/jjp.50.69
Abstract
Potentiating effects of .beta.-eudesmol on neuromuscular blockade were investigated in phrenic nerve-diaphragm muscles of normal and alloxan-diabetic mice. Pretreatment with .beta.-eudesmol potentiated the blocking effects of succinylcholine to a greater extent in diabetic muscles than in normal ones. This effect was saturated after 30-min pretreatment in normal muscles. Further potentiation was observed after 60-min pretreatment in diabetic muscles. These results suggest that .beta.-eudesmol modifies the sensitivity of diabetic mice to depolarizing blockers so that they have a higher susceptibility to these compounds.This publication has 5 references indexed in Scilit:
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