THE ORIGIN OF SPONTANEOUS MUTATIONS DURING MEIOSIS
- 1 November 1963
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 50 (5) , 975-980
- https://doi.org/10.1073/pnas.50.5.975
Abstract
It is shown that it is the meiotic behavior of chromosomes and not biochemical changes that is responsible for the increased spontaneous mutation rate during meiosis. Spontaneous reversions of the hi1-1 mutant occurring during a meiotic process are, in the great majority, associated with a chromosomal exchange. This association suggests that spontaneous mutations in meiosis are caused by unequal crossingover.Keywords
This publication has 7 references indexed in Scilit:
- SUPER-SUPPRESSORS IN YEAST1963
- THE STRUCTURE OF THE DNA-ACRIDINE COMPLEXProceedings of the National Academy of Sciences, 1963
- „SELFERS”—ATTRIBUTED TO UNEQUAL CROSSOVERS IN SALMONELLAProceedings of the National Academy of Sciences, 1962
- General Nature of the Genetic Code for ProteinsNature, 1961
- THE DIFFERENCE BETWEEN SPONTANEOUS AND BASE-ANALOGUE INDUCED MUTATIONS OF PHAGE T4Proceedings of the National Academy of Sciences, 1959