Retinal Oxidation Activity and Biological Role of Human Cytosolic Aldehyde Dehydrogenase
- 1 July 1992
- journal article
- research article
- Published by S. Karger AG in Enzyme
- Vol. 46 (4-5) , 239-244
- https://doi.org/10.1159/000468794
Abstract
The major cytosolic aldehyde dehydrogenase isozyme (ALDH1) exhibits strong activity for oxidation of retinal to retinoic acid, while the major mitochondrial ALDH2 and the stomach cytosolic ALDH3 have no such activity. The K(m) of ALDH1 for retinal is about 0.06 μmol/l at pH 7.5, and the catalytic efficiency (Vmax/Km) for retinal is about 600 times higher than that for acetaldehyde. Thus, ALDH1 can efficiently produce retinoic acid from retinal in tissues with low retinal concentrations (Keywords
This publication has 0 references indexed in Scilit: