The first arch syndrome is a group of conditions in which anatomical and physiological abnormalities are found in the area supplied by the vessels of the first visceral arch in early embryonic life. Anomalies of the first visceral arch produce the defects of the syndrome by modifications of the blood supply to the rapidly growing and differentiating embryonic tissues. The disease is hereditary. Waardenburg's syndrome consists of deafness, heterochromia, a white forelock, and various anatomical changes. An unusual case is presented, showing extensive partial albinism in addition to many of the stigmata of Waardenburg's syndrome. Genetic and nutritional factors in relation to the first arch syndrome are discussed.