Fructose-1,6-bisphosphate reduces infarct volume after reversible middle cerebral artery occlusion in rats.
- 1 October 1993
- journal article
- abstracts
- Published by Wolters Kluwer Health in Stroke
- Vol. 24 (10) , 1576-1583
- https://doi.org/10.1161/01.str.24.10.1576
Abstract
We tested the hypothesis that fructose-1,6-bisphosphate, when administered 10 minutes before the end of 2 hours of reversible middle cerebral artery occlusion, reduces ischemia-reperfusion injury and infarct volume measured after a 3-day survival period in rats.After 1 hour and 50 minutes of middle cerebral artery occlusion by the intraluminal suture method, fructose-1,6-bisphosphate, 500 mg/kg in group 1 and 350 mg/kg in group 2 (or an equivalent volume of 1.8% saline as placebo in each group), was given intravenously for a period of 15 minutes to fasted adult Sprague-Dawley rats. After 2 hours of ischemia, the suture was withdrawn and the rats allowed to survive for 3 days. The areas of infarction in 10 hematoxylin-eosin-stained coronal sections of the brain were measured and used to calculate infarct volume.In group 1, fructose-1,6-bisphosphate decreased total cerebral hemispheric infarct volume by 43% (from 199.6 +/- 11.2 to 114.2 +/- 35.8 mm3, P < .04; mean +/- SEM). Cerebral cortical and subcortical...Keywords
This publication has 25 references indexed in Scilit:
- Fructose-l,6-bisphosphate does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pigCritical Care Medicine, 1992
- The Significance of Brain Temperature in Focal Cerebral Ischemia: Histopathological Consequences of Middle Cerebral Artery Occlusion in the RatJournal of Cerebral Blood Flow & Metabolism, 1992
- Fructose-1,6-bisphosphate, when given immediately before reoxygenation, or before injury, does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pigCritical Care Medicine, 1991
- Oxygen Radical Injury and Loss of High-Energy Compounds in Anoxic and Reperfused Rat Heart: Prevention By Exogenous Fructose-1, 6-BisphosphateFree Radical Research Communications, 1990
- Improved brain metabolism with fructose 1-6 diphosphate during insulin-induced hypoglycemic comaThe Lancet Healthy Longevity, 1989
- Some effects of fructose‐1,6‐diphosphate on rat myocardial tissue related to a membrane‐stabilizing actionCell Biochemistry and Function, 1989
- Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal InjuryJournal of Cerebral Blood Flow & Metabolism, 1987
- Effects of Fructose-1,6-Diphosphate, Glucose, and Saline on Cardiac ResuscitationAnesthesiology, 1986
- Hemodynamic and electrocardiographic effects of fructose-1,6-diphosphate in acute myocardial infarctionThe American Journal of Cardiology, 1985
- FDP-activation of yeast pyruvate kinaseBiochemical and Biophysical Research Communications, 1966