Protein Biosynthesis in the Testis: I. Comparison Between Stimulation by FSH and Glucose

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Abstract
Stimulation of protein biosynthesis in rat testis by glucose was studied in rats of various ages and in hypophysectomized animals. Glucose did not increase protein synthesis in the testis before the age of 28 days and the stimulation observed in the adult gradually declined following hypophysectomy until no response was observed 25 days after operation. It has been reported that spermatids appear at 28 days of age and disappear from the adult testis within 25 days after hypophysectomy. Our findings support previous suggestions that glucose stimulates protein biosynthesis in spermatids. A single injection of FSH stimulates protein biosynthesis in testes of rats aged 15–24 days but not in testes of rats more than 24 days of age. The adult testis responds to FSH within 18 hr of hypophysectomy and continues to respond to a single injection for at least 25 days after operation. FSH appears to increase protein biosynthesis whether spermatids are present or not, in keeping with earlier histological reports indicating that FSH acts chiefly upon primary spermatocytes. It appears that the 2 substances FSH and glucose stimulate protein synthesis in different cell types—glucose acting primarily on spermatids and FSH on some or all of the remaining cell types of the germinal epithelium. (Endocrinology82: 597, 1968)

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