Rift Valley Fever Virus in the One-Day-Old Chick Embryo

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Abstract
Summary: Rift valley fever virus, pantropic and neurotropic, proliferates very well when inoculated in the blastoderm of the 1-day-old hen's egg. Parallel titrations gave slightly lower titers in day-old embryos than in mice with both the pantropic and neurotropic viruses. The virus multiplication declines with the age of the developing embryo. Embryos of two or three days of age support virus multiplication as well as those one day old and then multiplication declines to a very low level by seven days of age. Serial passage of the virus was readily accomplished in day-old embryos. However, during the course of the serial passage, the virus showed no changes in antigenicity, pathogenicity for mice or growth rate in fertile eggs of various ages.

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