Monocyte Chemoattractant Protein 1 Does Not Contribute to Protective Immunity against Pneumococcal Pneumonia
- 1 December 2006
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (12) , 7021-7023
- https://doi.org/10.1128/iai.00977-06
Abstract
To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected withStreptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality.Keywords
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