Iopamidol: a non-ionic contrast agent for peripheral arteriography.

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Abstract
Patients (10) undergoing peripheral arteriography with iopamidol were evaluated in a carefully controlled Phase I study using a variety of objective and subjective tests of discomfort. There was minimal objective evidence of pain, and the patients reported that they perceived minor discomfort and a warm sensation during the contrast injections. Patients (5) who had previously undergone arteriography with 2 mg lidocaine/ml methylglucamine diatrizoate noted a marked decrease in discomfort when iopamidol was used. Opacification of peripheral arteries was excellent. Multiple physical examinations, chemical tests, ECG and intraaterial pressure recordings showed that iopamidol is safe.

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