Regeneration of the Mammalian Liver III. Electrokinetics of Replicating Cells Treated with Anti-Mitotic Antibiotics.

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Abstract
Summary Following amputation of approximately 70% of a rat's liver, there ensues a period of active nucleic acid synthesis followed by a wave of cell division. Surface alterations occur during the preparation for mitosis which result in an increase of electro-phoretic mobility and it has been suggested that cell division is dependent upon surface charge. The present study demonstrates that the assumption of increased electrostatic charge during the preparation for cell division is not the result of newly synthesized protein and in accord with previous work indicates that cell division is independent of surface charge. However, it was suggested that the total surface charge of interphase cells is related to the constant synthesis of surface proteins.

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