Methods Development for On-Line Gas Chromatography

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Abstract
On-line gas chromatography for continuous process analysis and control imposes special requirements on the development of analytical methods and selection of hardware. The special considerations for methods development for on-line analysis are compared with those for laboratory use. The properties of the process sample, such as dewpoint and bubblepoint, the need for handling process upset conditions, and the need for operating in hazardous locations affect key elements in the design of the method and the selection and location of the sample injection system. The evolution of on-line methods has emphasized multicolumn and column switching methods to improve reliability and increase speed. Computer-aided selection and optimization of capillary column parameters is used to design for speed of analysis while satisfying requirements of minimum FID detectability or compatibility with small-volume thermal conductivity detectors. Series-coupled columns with different phases are more effective in optimizing for speed of analysis by improving separation factors of measured components. Computer-aided optimization of series-coupled columns overcomes design problems related to carrier gas compressibility and differences in column dimensions.

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