Replication and Interaction of Virus DNA and Cellular DNA in Mouse Cells Infected by a Human Adenovirus
- 1 November 1979
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 45 (2) , 455-467
- https://doi.org/10.1099/0022-1317-45-2-455
Abstract
C57 black mouse cells infected with human adenovirus type 5 (Ad5) produced large amounts of early virus proteins, small amounts of late virus proteins and less than 0.2 infectious units (i.u.)/cell of infectious virus. Many cells died but the cultures recovered. Virus DNA and cellular DNA were synthesized. Some Ad5 DNA sedimented with cell DNA in alkaline sucrose, but virus DNA was rapidly lost from the culture after recovery and none of 28 unselected cloned survivors contained detectable amounts of virus DNA or antigens.This publication has 0 references indexed in Scilit: