PROMOTION OF AZOXYMETHANE-INDUCED INTESTINAL CANCER BY HIGH-FAT DIET IN RATS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (12) , 4956-4959
Abstract
Promotional properties of a high-fat diet in intestinal cancer were studied by feeding a 30% beef fat diet to 8 groups of rats (25 rats/group) for time periods varying from 1 to 21 wk after 8 weekly s.c. injections of azoxymethane (AOM) (8 mg/kg). Two other groups were fed the high-fat diet, one for 8 wk prior to and the other during AOM injections. A 5% fat diet was fed to rats when not on the 30% fat diet and to a control group of 25 animals. High-fat diet increased intestinal tumor frequency up to 2-fold when given for at least 4 wk after but not during or prior to AOM injections; this increase occurred even after a prolonged interval (10 wk) between the last AOM injection and the high-fat diet. In general, tumor frequency increased according to the length of time animals were fed the high-fat diet after AOM. The high-fat diet in this model exhibited most of the properties of promoters developed from murine skin cancer, adding support to the concept that excess dietary fat acts at the promotional phase of carcinogenesis.