ANALGESIC STUDIES WITH NEFOPAM HYDROCHLORIDE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 226  (1) , 156-171
Abstract
Nefopam hydrochloride [5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-2,5 benz[f] oxazocine hydrochloride] is a novel analgesic agent possessing an activity profile distinct from that of narcotic, narcotic agonist-antagonist and analgesic antiinflammatory agents. Analgesic activity is demonstrated in a variety of laboratory procedures with rodents, cats and monkeys. The analgesic potency of nefopam hydrochloride is generally similar to that of codeine phosphate. The compound apparently lacks potential for tolerance development and does not exhibit cross-tolerance with morphine sulfate.