Lack of Erythroid Characteristics in la-Positive Leukemia Cell Lines Induced by Friend Murine Leukemia Virus: Brief Communication 2

Publisher Website
Google Scholar
Abstract
A group of mouse leukemia cell lines induced by the Friend murine leukemia virus (F-MuLV) was examined for la cell membrane antigens (regulated by the l-region of the H-2 complex), as well as for erythroid characteristics. Erythroid traits tested were hemoglobin synthesis, incorporation of59Fe into heme, and presence of globin mRNA. Of 19 lines, 13 were positive for erythroid characteristics. All of these 13 lines were la-negative. Of 19 lines, 6 were negative for erythroid characteristics, and 5 of the 6 were la-positive. The data suggested that F-MuLV-induced leukemogenesis may operate in more than 1 cell type. In addition to the primitive erythroid type of cell usually involved in leukemia induced by F-MuLV, nonerythroid la-positive cells may also be transformed. The exact origin of the la-positive leukemia cells is unknown.