SENSITIVITY OF NEONATAL RABBIT ILEUM TO HISTAMINE

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Abstract
Segments of ileum from newborn rabbits contracted in response to histamine but sensitivity declined from age 11 days. Intestine from adult animals barely contracted to histamine, even in a concentration of 3 × 10−3 M. Such variation with age was not observed with acetylcholine. The response to histamine was effected by mepyramine-sensitive receptors which appeared to decrease in number as the animals aged.

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