Association of Factors XI and XII with Blood Platelets.

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Abstract
Summary Normal platelets were subjected to successive saline washes and measurements made of factors V, VII and X, XI and XII in the resuspended platelets. Factor XI behaved like factor V in remaining with the platelet through 10 successive washes. Factor XII, on the other hand, like factor VII and X, was readily removed by one or two washes. Factor XI-deficient platelets when suspended in normal plasma absorbed over 30% of the factor XI from the plasma. Absorbed factor XI was removed by 4 washes. The potential significance of those clotting factors which tightly adsorb to platelets is discussed.