Peroxisome proliferator-activated receptor γ and atherosclerosis
- 1 February 2002
- journal article
- Published by Springer Nature in Current Hypertension Reports
- Vol. 4 (1) , 71-77
- https://doi.org/10.1007/s11906-002-0056-8
Abstract
Within the past couple of years, peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor expressed in vascular cells, has received growing interest in vascular biology and atherosclerosis research. Initially, PPARγ was identified as a regulator of gene expression in lipid metabolism and adipogenesis, but recent data in monocyte/macrophages, endothelial cells, and vascular smooth muscle cells suggest that PPARγ might have anti-inflammatory effects in atherogenesis. However, with growing insight, there is much controversy about potential anti- or proatherosclerotic effects. This review will focus on these aspects and discuss what PPARγ activation in vascular cells could mean for atherogenesis and the development of atherosclerosis.Keywords
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