Reshaping human antibodies for therapy
- 1 March 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 332 (6162) , 323-327
- https://doi.org/10.1038/332323a0
Abstract
A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.Keywords
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