Ribonucleic Acid Biosynthesis in Adult and Infant Rat Brain in vitro
- 4 April 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 164 (3875) , 79-80
- https://doi.org/10.1126/science.164.3875.79
Abstract
The rate of biosynthesis of ribonucleic acid (as judged by the rate of incorporation of uridine into ribonucleic acid) in infant and adullt rat brain cortex slices, incubated (aerobically in tile presenice of various substrates, is directly proportionial to the adenosine triphosphate concentration. This suggests that the adenosine triphosphate concentration is one of the factors involved in the control of ribonucleic acid biosynthesis in infant and adult rat brain. Acetoacetate or beta-hydroxybutyrate is about 70 percent as effective as glucose, with both infant and adult brain, for the promotion of ribonucleic acid biosynthesis. but they are considerably mnore effective than succinate in infant brain than in adult brain.Keywords
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- THE EFFECTS OF MATURATION ON IN VITRO RNA SYNTHESIS BY MOUSE BRAIN CELLS *Journal of Neurochemistry, 1967
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