Regulation of fetal placental blood flow in the lamb

Publisher Website
Google Scholar
Abstract
Inflatable occluders were placed on the distal aorta of 11 fetal lambs. After 1 wk of control measurements, fetal placental blood flow was reduced to about 2/3 of its control value for an average period of 2 wk. No allowance was made for fetal growth. During the period of flow restriction, fetal growth was 2% day. Femoral arterial blood pressure was reduced from a control value of 41-27 mmHg (P < 0.001). There was an insignificant increase in carotid arterial blood pressure from 48-50 mmHg. Placental resistance to flow did not decrease more than could be accounted for by the increase in gestational age in the course of the experiment. Fetal placental blood flow is not under feedback control, since neither of the determinants of flow (i.e., driving pressure and resistance) responded to its chronic reduction.

This publication has 7 references indexed in Scilit: