On the Solubility of Fibrin Clots

Publisher Website
Google Scholar
Abstract
A clot obtained in purified fibrinogen soln. or in oxalated plasma by the action of purified thrombin dissolves readily when an equal vol. of 60% urea is added to the clot. The clot formed in recalcified plasma by its own thrombin, however, does not dissolve in urea soln. Two factors are responsible for making the clot insoluble in urea soln. One factor is the Ca ions and the other is some serum component which seems to be thermolabile. Adding these 2 factors in sufficient amts. to purified fibrinogen prior to addition of thrombin, results in an insoluble clot. Neither factor alone makes the clot insoluble.

This publication has 1 reference indexed in Scilit: